Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 15/20 | 0.34 |
| ▸ | PYGL | P06737 | 2/20 | 0.32 |
| ▸ | PYGM | P11217 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964717 | 0.82 | RIPK1 (0.42) | RIPK1PYGLPYGM | |
| SCHEMBL15957171 | 0.78 | RIPK1 (0.43) | RIPK1PYGLPYGM | |
| SCHEMBL15956781 | 0.74 | MAPT (0.35) | BRD4CYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL15956786 | 0.74 | MAPT (0.35) | BRD4CYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL17312837 | 0.72 | GSK3B (0.32) | RIPK1PDE3BPDE3A | |
| SCHEMBL17312839 | 0.72 | GSK3B (0.32) | RIPK1PDE3BPDE3A | |
| SCHEMBL15964811 | 0.70 | RIPK1 (0.54) | RIPK1PYGLPYGM | |
| SCHEMBL17312793 | 0.70 | RIPK1 (0.54) | RIPK1PYGLPYGM | |
| SCHEMBL15957161 | 0.67 | GSK3B (0.47) | CYP1A2CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL8812696 | 0.65 | PDE3B (0.59) | BRD4CYP1A2CYP11B1CYP11B2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |