Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | PPID | Q08752 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13212654 | 0.85 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL15334000 | 0.85 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL12481397 | 0.85 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL25882415 | 0.84 | MAPT (0.51) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL19980197 | 0.81 | MEN1 (0.48) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL13406756 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL25882277 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL14606969 | 0.79 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2PPIDMAPTLMNA | |
| SCHEMBL23771890 | 0.72 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPTLMNAGAA | |
| SCHEMBL7538405 | 0.72 | SMN1; SMN2 (0.66) | ALDH1A1SMN1; SMN2MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |