Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17321246 | 0.90 | MAPT (0.47) | LMNARIPK1ALDH1A1MAPK1TDP1 | |
| SCHEMBL17321225 | 0.86 | SMN1; SMN2 (0.45) | LMNARIPK1ALDH1A1 | |
| SCHEMBL15964590 | 0.86 | RIPK1 (0.40) | RIPK1ALDH1A1 | |
| SCHEMBL23189065 | 0.85 | MAPT (0.45) | LMNARIPK1ALDH1A1MAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL29271402 | 0.85 | SMN1; SMN2 (0.44) | RIPK1ALDH1A1 | |
| SCHEMBL29271326 | 0.83 | HPGD (0.53) | ALDH1A1MAPK1 | |
| SCHEMBL29271276 | 0.83 | HPGD (0.50) | ALDH1A1 | |
| SCHEMBL29271299 | 0.82 | CHRNB4 (0.39) | LMNARIPK1ALDH1A1MAPK1 | |
| SCHEMBL15964769 | 0.82 | HPGD (0.51) | TDP1GAA | |
| Hydrochloric Acid SCHEMBL30986628 | 0.82 | HPGD (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |