Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.72 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.69 |
| ▸ | MRGPRX4 | Q96LA9 | 9/20 | 0.62 |
| ▸ | MAOB | P27338 | 3/20 | 0.62 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.62 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PTPRC | P08575 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387246 | 0.90 | NR4A2 (0.77) | F10PARP10MRGPRX4MAOBNR4A2 | |
| Hydrochloric Acid SCHEMBL27603151 | 0.89 | NR4A2 (0.74) | F10PARP10MAOBNR4A2F2 | |
| SCHEMBL4138759 | 0.87 | NR4A2 (0.81) | MRGPRX4NR4A2TP53PKMNFKB1 | |
| SCHEMBL15452708 | 0.86 | PARP10 (0.74) | PARP10MRGPRX4MAOBPARP15PARP14 | |
| SCHEMBL18297488 | 0.86 | PARP10 (0.62) | F10PARP10MRGPRX4MAOBPARP15 | |
| SCHEMBL17384527 | 0.86 | PARP10 (0.68) | F10PARP10MRGPRX4MAOBPARP15 | |
| SCHEMBL14169334 | 0.86 | SMN1; SMN2 (0.76) | PARP10MRGPRX4MAOBPARP15PARP14 | |
| SCHEMBL202497 | 0.84 | F2 (0.61) | PARP10MAOBPARP15PARP14NR4A2 | |
| SCHEMBL23189125 | 0.84 | MAOB (0.82) | F10MRGPRX4MAOBTP53PKM | |
| SCHEMBL10814674 | 0.84 | F10 (0.68) | F10MRGPRX4MAOBNR4A2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |