Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23189006 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL3355913 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL3355917 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL11569645 | 0.76 | KMT2A (0.50) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL11569649 | 0.76 | KMT2A (0.50) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL30223355 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL30223215 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL12409354 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL4812101 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2USP2HPGDTP53ALOX12 | |
| SCHEMBL1101625 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2USP2HPGDTP53ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |