Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.58 |
| ▸ | BCHE | P06276 | 2/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 14/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964918 | 0.74 | BCHE (0.42) | ACHEBCHE | |
| SCHEMBL7523915 | 0.74 | TSHR (0.58) | — | |
| SCHEMBL31634587 | 0.72 | TSHR (0.51) | — | |
| SCHEMBL18985930 | 0.72 | ACHE (0.66) | ACHEBCHES1PR1AOC3 | |
| SCHEMBL25586358 | 0.71 | PTGDR2 (0.48) | — | |
| SCHEMBL30955218 | 0.71 | ACHE (0.64) | ACHEBCHES1PR1 | |
| SCHEMBL10791590 | 0.71 | USP2 (0.57) | — | |
| SCHEMBL27436286 | 0.71 | ACHE (0.64) | ACHEBCHES1PR1 | |
| SCHEMBL10171195 | 0.69 | S1PR1 (0.69) | S1PR1S1PR3 | |
| SCHEMBL21938893 | 0.69 | ACHE (0.67) | ACHEBCHES1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |