Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071952 | 0.81 | TSHR (0.54) | LMNACYP2A6SMN1; SMN2L3MBTL1CYP2E1 | |
| SCHEMBL7245616 | 0.80 | HPGD (0.46) | HPGDLMNAMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL752273 | 0.72 | TOP2A (0.46) | HPGDLMNAMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL15965379 | 0.70 | F2 (0.44) | HPGDCYP2D6LMNAMAPK1L3MBTL1 | |
| SCHEMBL2068845 | 0.69 | CYP2C9 (0.50) | HPGDCYP2D6LMNADPP4ALOX5 | |
| SCHEMBL6829494 | 0.69 | CYP2A6 (0.37) | HPGDAPPDPP4CYP2A6IDO1 | |
| SCHEMBL9226050 | 0.69 | DAO (0.45) | HPGDAPPDPP4CYP2A6KDM4E | |
| SCHEMBL5366910 | 0.69 | ALDH1A1 (0.41) | HPGDAPPDPP4ALOX5CYP2A6 | |
| Diphenylmethanol SCHEMBL15641329 | 0.68 | SMN1; SMN2 (0.58) | CYP2D6LMNAMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL6829741 | 0.68 | ALDH1A1 (0.36) | HPGDAPPDPP4ALOX5CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |