Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11990868 | 0.84 | PDK2 (0.56) | PDK2KMT2ACYP1A2CYP2C19GAA | |
| SCHEMBL30322608 | 0.84 | PDK2 (0.56) | PDK2KMT2ACYP1A2CYP2C19GAA | |
| SCHEMBL19567070 | 0.84 | PDK2 (0.37) | PDK2KMT2ACYP1A2CYP2C19MAOA | |
| SCHEMBL32682807 | 0.82 | PDK2 (0.49) | PDK2KMT2ACYP1A2CYP2C19GAA | |
| SCHEMBL29419598 | 0.82 | PDK2 (0.49) | PDK2KMT2ACYP1A2CYP2C19GAA | |
| SCHEMBL5344736 | 0.82 | PDK2 (0.49) | PDK2KMT2ACYP1A2CYP2C19GAA | |
| SCHEMBL19980423 | 0.81 | ALDH1A1 (0.39) | PDK2KMT2ACYP1A2CYP2C19MAOA | |
| SCHEMBL19567023 | 0.81 | ALDH1A1 (0.39) | PDK2KMT2ACYP1A2CYP2C19MAOA | |
| SCHEMBL19974426 | 0.80 | ALDH1A1 (0.54) | PDK2KMT2ACYP1A2LMNAALDH1A1 | |
| SCHEMBL29516015 | 0.80 | ALDH1A1 (0.54) | PDK2KMT2ACYP1A2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
| WO-2018050584-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | PDK2 835/4885KMT2A 3037/4885CYP1A2 787/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | PDK2 835/4885KMT2A 3037/4885CYP1A2 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.