Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | DRD3 | P35462 | 6/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19972510 | 1.00 | HTR2A (0.40) | HTR2ADRD3OPRM1OPRK1OPRL1 | |
| SCHEMBL19972513 | 1.00 | HTR2A (0.40) | HTR2ADRD3OPRM1OPRK1OPRL1 | |
| SCHEMBL19972578 | 0.94 | OPRM1 (0.38) | HTR2ADRD3OPRM1OPRK1OPRL1 | |
| SCHEMBL19972669 | 0.94 | OPRM1 (0.38) | HTR2ADRD3OPRM1OPRK1OPRL1 | |
| SCHEMBL19972654 | 0.94 | HTR2A (0.48) | HTR2ADRD3DRD2 | |
| SCHEMBL19972657 | 0.94 | HTR2A (0.48) | HTR2ADRD3DRD2 | |
| SCHEMBL19972462 | 0.91 | OPRM1 (0.41) | OPRM1OPRK1OPRL1MEN1KMT2A | |
| SCHEMBL30265628 | 0.91 | OPRM1 (0.41) | OPRM1OPRK1OPRL1MEN1KMT2A | |
| SCHEMBL19972463 | 0.91 | OPRM1 (0.41) | OPRM1OPRK1OPRL1MEN1KMT2A | |
| SCHEMBL30524094 | 0.91 | OPRM1 (0.41) | OPRM1OPRK1OPRL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359610-A | MENIN-MLL interaction inhibitors | 生命医药有限责任公司 | 2024-07-19 | — | — | CN | disclosed |
| EP-4230627-A2 | INHIBITORS OF THE MENIN-MLL INTERACTION | Vitae Pharmaceuticals, LLC (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3512850-B1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS LLC (US) | 2023-04-12 | — | — | EP | disclosed |
| WO-2018053267-A1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |