Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19972686 | 0.92 | KDM4C (0.36) | KDM4CNFATC1GSK3BDYRK1ARORC | |
| SCHEMBL19972688 | 0.92 | KDM4C (0.36) | KDM4CNFATC1GSK3BDYRK1ARORC | |
| SCHEMBL23515871 | 0.92 | KDM4C (0.36) | KDM4CNFATC1GSK3BDYRK1ARORC | |
| SCHEMBL31001728 | 0.90 | KDM4C (0.35) | KDM4COPRM1NFATC1GSK3BDYRK1A | |
| SCHEMBL19972484 | 0.90 | KDM4C (0.38) | KDM4CMEN1KMT2A | |
| SCHEMBL19972486 | 0.90 | KDM4C (0.38) | KDM4CMEN1KMT2A | |
| SCHEMBL26036581 | 0.89 | RORC (0.34) | KDM4COPRM1OPRK1OPRL1RORC | |
| SCHEMBL30524044 | 0.89 | MEN1 (0.45) | KDM4CMEN1KMT2A | |
| SCHEMBL19972521 | 0.89 | MEN1 (0.45) | KDM4CMEN1KMT2A | |
| SCHEMBL19972524 | 0.89 | MEN1 (0.45) | KDM4CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4230627-A2 | INHIBITORS OF THE MENIN-MLL INTERACTION | Vitae Pharmaceuticals, LLC (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3512850-B1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS LLC (US) | 2023-04-12 | — | — | EP | disclosed |
| WO-2018053267-A1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |