Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25775999 | 0.84 | — | — | |
| SCHEMBL14654989 | 0.82 | TSHR (0.36) | ALDH1A1KDM4EPOLBGAAHSD11B1 | |
| SCHEMBL15871584 | 0.79 | KDM4E (0.32) | ALDH1A1KDM4EPOLB | |
| SCHEMBL15443878 | 0.79 | KDM4E (0.32) | ALDH1A1KDM4EPOLB | |
| SCHEMBL20019724 | 0.76 | PIM1 (0.34) | ALDH1A1KDM4EPOLB | |
| SCHEMBL20019698 | 0.76 | CA12 (0.33) | — | |
| SCHEMBL19981643 | 0.71 | CHRNA7 (0.32) | ALDH1A1KDM4EPOLBCHRNA7 | |
| SCHEMBL19981427 | 0.70 | MEN1 (0.31) | KMT2A | |
| SCHEMBL14417614 | 0.70 | GAA (0.38) | ALDH1A1KDM4EGAASMN1; SMN2HSD17B10 | |
| SCHEMBL20352233 | 0.69 | KDM4E (0.43) | ALDH1A1KDM4EPOLBGAAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |