Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25775999 | 0.84 | — | — | |
| SCHEMBL14654991 | 0.79 | TSHR (0.33) | KDM4EALDH1A1POLB | |
| SCHEMBL15871585 | 0.77 | KDM4E (0.31) | KDM4EALDH1A1POLB | |
| SCHEMBL20019698 | 0.76 | CA12 (0.33) | — | |
| SCHEMBL19981425 | 0.71 | ALDH1A1 (0.34) | CHRNA7KDM4EALDH1A1POLB | |
| SCHEMBL19981427 | 0.70 | MEN1 (0.31) | — | |
| SCHEMBL14417614 | 0.70 | GAA (0.38) | KDM4EALDH1A1 | |
| SCHEMBL14995005 | 0.68 | HRH3 (0.33) | CHRNA7KDM4EALDH1A1 | |
| SCHEMBL13290568 | 0.68 | CHRNA7 (0.46) | CHRNA7KDM4EALDH1A1 | |
| SCHEMBL681912 | 0.68 | CHRNA7 (0.46) | CHRNA7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |