Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TEC | P42680 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981863 | 0.83 | BTK (0.44) | BTKFGRSRCTECBMX | |
| SCHEMBL19981880 | 0.80 | BTK (0.58) | BTKFGRSRCTECBMX | |
| SCHEMBL9986674 | 0.80 | BTK (0.62) | BTKFGRSRCTECBMX | |
| SCHEMBL2461827 | 0.79 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL2490923 | 0.78 | BTK (0.60) | BTKFGRSRCTECBMX | |
| SCHEMBL2463872 | 0.77 | BTK (0.59) | BTKFGRSRCTECBMX | |
| SCHEMBL2462161 | 0.74 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL19981771 | 0.74 | BTK (0.50) | BTKFGRSRCTECBMX | |
| SCHEMBL2492181 | 0.73 | BTK (0.61) | BTKFGRSRCTECBMX | |
| SCHEMBL2463870 | 0.73 | BTK (0.61) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |