Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 13/20 | 0.50 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TEC | P42680 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981684 | 0.86 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL9986674 | 0.86 | BTK (0.62) | BTKFGRSRCTECBMX | |
| SCHEMBL19981660 | 0.83 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL19981864 | 0.81 | BTK (0.49) | BTKFGRSRCTECBMX | |
| SCHEMBL19981777 | 0.80 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL19981682 | 0.78 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL19981754 | 0.77 | BTK (0.55) | BTKFGRSRCTECBMX | |
| SCHEMBL19981880 | 0.77 | BTK (0.58) | BTKFGRSRCTECBMX | |
| SCHEMBL19981784 | 0.75 | BTK (0.47) | BTKFGRSRCTECBMX | |
| SCHEMBL19981536 | 0.74 | BTK (0.47) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |