Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.49 |
| ▸ | BTK | Q06187 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492566 | 0.84 | BTK (0.60) | NAMPTBTKKDM4E | |
| SCHEMBL13894014 | 0.80 | BTK (0.46) | NAMPTBTKKDM4ELMNAPOLB | |
| SCHEMBL13894021 | 0.75 | BTK (0.39) | NAMPTBTKKDM4ELMNAPOLB | |
| SCHEMBL105574 | 0.73 | BTK (0.66) | BTK | |
| SCHEMBL105793 | 0.73 | BTK (0.59) | BTK | |
| SCHEMBL107601 | 0.73 | BTK (0.60) | BTKKDM4E | |
| SCHEMBL104664 | 0.72 | BTK (0.56) | BTK | |
| SCHEMBL3659635 | 0.71 | BTK (0.61) | BTK | |
| SCHEMBL104439 | 0.71 | BTK (0.77) | BTK | |
| SCHEMBL108055 | 0.71 | BTK (0.58) | BTKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |