Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981933 | 1.00 | BTK (0.44) | BTKSYKFGRSRCTEC | |
| SCHEMBL19981898 | 0.89 | BTK (0.36) | BTK | |
| SCHEMBL19981559 | 0.88 | BTK (0.41) | BTKSYKFGRSRCTEC | |
| SCHEMBL16357030 | 0.82 | BTK (0.47) | BTKSYKFGRSRCTEC | |
| SCHEMBL10262845 | 0.82 | BTK (0.49) | BTKSYKFGRSRCTEC | |
| SCHEMBL13303603 | 0.79 | SYK (0.48) | BTKSYK | |
| SCHEMBL14929644 | 0.79 | BTK (0.44) | BTKSYKFGRSRCTEC | |
| SCHEMBL2488047 | 0.77 | SYK (0.37) | BTKSYKFGRSRCTEC | |
| SCHEMBL9984843 | 0.77 | BTK (0.47) | BTKSYK | |
| SCHEMBL2494684 | 0.75 | SYK (0.40) | BTKSYKFGRSRCTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |