Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981572 | 0.89 | BTK (0.44) | BTK | |
| SCHEMBL19981933 | 0.89 | BTK (0.44) | BTK | |
| SCHEMBL19981559 | 0.78 | BTK (0.41) | BTK | |
| SCHEMBL2488047 | 0.72 | SYK (0.37) | BTK | |
| SCHEMBL10262845 | 0.71 | BTK (0.49) | BTK | |
| SCHEMBL16357030 | 0.71 | BTK (0.47) | BTK | |
| SCHEMBL2492299 | 0.69 | BTK (0.47) | BTK | |
| SCHEMBL13303603 | 0.69 | SYK (0.48) | BTK | |
| SCHEMBL14929644 | 0.68 | BTK (0.44) | BTK | |
| SCHEMBL10255860 | 0.65 | TYK2 (0.47) | BTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |