Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464078 | 0.79 | BTK (0.59) | BTKFGRSRCTECBMX | |
| SCHEMBL2466168 | 0.79 | BTK (0.59) | BTKFGRSRCTECBMX | |
| SCHEMBL2464076 | 0.79 | BTK (0.59) | BTKFGRSRCTECBMX | |
| SCHEMBL2467939 | 0.71 | BTK (0.66) | BTKFGRSRCTECBMX | |
| SCHEMBL9985729 | 0.67 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL2491394 | 0.67 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL9985142 | 0.67 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL9984772 | 0.66 | BTK (1.00) | BTKFGRSRCTECBMX | |
| SCHEMBL2464013 | 0.64 | BTK (0.38) | BTK | |
| SCHEMBL2462645 | 0.64 | BTK (0.38) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |