Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.53 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492191 | 0.89 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL2490980 | 0.81 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL2488504 | 0.78 | BTK (0.51) | BTK | |
| SCHEMBL2493674 | 0.78 | BTK (0.77) | BTKFGRSRCTECBMX | |
| SCHEMBL2528193 | 0.75 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL2461982 | 0.74 | BTK (0.45) | BTKHDAC3NPC1SMN1; SMN2 | |
| SCHEMBL19981913 | 0.73 | NTRK1 (0.38) | BTK | |
| SCHEMBL9984851 | 0.73 | BTK (0.46) | BTKNPC1SMN1; SMN2 | |
| SCHEMBL2461847 | 0.72 | BTK (0.72) | BTKFGRSRCTECBMX | |
| SCHEMBL9984872 | 0.71 | BTK (0.69) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |