Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | IGF1R | P08069 | 8/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984917 | 0.89 | BTK (0.43) | NTRK1PLK4BTKCCNA2CDK2 | |
| SCHEMBL2491732 | 0.77 | BTK (0.50) | BTK | |
| SCHEMBL2464012 | 0.75 | BTK (0.52) | NTRK1PLK4BTKCCNA2CDK2 | |
| SCHEMBL19981627 | 0.73 | BTK (0.53) | BTK | |
| SCHEMBL2461982 | 0.71 | BTK (0.45) | BTK | |
| SCHEMBL19981766 | 0.71 | BTK (0.41) | BTK | |
| SCHEMBL9984851 | 0.70 | BTK (0.46) | BTK | |
| SCHEMBL2492191 | 0.69 | BTK (0.63) | BTK | |
| SCHEMBL9984746 | 0.69 | BTK (0.45) | NTRK1BTKSYK | |
| SCHEMBL2488504 | 0.69 | BTK (0.51) | BTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |