Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.31 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465624 | 0.83 | BTK (0.55) | BTKROCK2ROCK1HDAC1HDAC2 | |
| SCHEMBL19981931 | 0.72 | BTK (0.44) | BTKHDAC1BCL6 | |
| SCHEMBL19981770 | 0.69 | BTK (0.42) | BTKHDAC1BCL6MAPK14TMIGD3 | |
| SCHEMBL2493858 | 0.67 | BTK (0.59) | BTKBCL6PDCD1CD274WDR5 | |
| SCHEMBL9987266 | 0.67 | BTK (0.44) | BTKHDAC1HDAC2BCL6TMIGD3 | |
| SCHEMBL2462161 | 0.67 | BTK (0.63) | BTKHDAC1HDAC2BCL6TMIGD3 | |
| SCHEMBL2467451 | 0.66 | BTK (0.58) | BTKHDAC1HDAC2BCL6TMIGD3 | |
| SCHEMBL2465846 | 0.66 | BTK (0.58) | BTKHDAC1HDAC2BCL6PDCD1 | |
| SCHEMBL19981722 | 0.66 | BTK (0.46) | BTKBCL6 | |
| SCHEMBL2464067 | 0.66 | BTK (0.58) | BTKROCK2HDAC1HDAC2BCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |