Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.38 |
| ▸ | CCND1 | P24385 | 4/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 7/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TEC | P42680 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 6/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461862 | 0.82 | BTK (0.67) | BTKCDK6CCND1BCL6CCND3 | |
| SCHEMBL19981804 | 0.81 | BTK (0.40) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2461953 | 0.76 | BTK (0.66) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2462150 | 0.73 | BTK (0.64) | BTKCCND1BCL6FGRSRC | |
| SCHEMBL9985071 | 0.72 | BTK (0.41) | BTKBCL6FGRSRCTEC | |
| SCHEMBL2467544 | 0.72 | BTK (0.62) | BTKBCL6FGRSRCTEC | |
| SCHEMBL9984681 | 0.72 | BTK (0.55) | BTKCDK6CCND1CCND3CCNE2 | |
| SCHEMBL2459433 | 0.72 | BTK (0.54) | BTKCDK6CCND1BCL6CCND3 | |
| SCHEMBL2491555 | 0.71 | BTK (0.64) | BTKBCL6FGRSRCTEC | |
| SCHEMBL19981770 | 0.71 | BTK (0.42) | BTKBCL6FGRSRCTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |