Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 11/20 | 0.35 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | BCL6 | P41182 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12025103 | 1.00 | MPL (0.35) | MPLBTKACP1TYK2SCN9A | |
| SCHEMBL12025119 | 1.00 | MPL (0.35) | MPLBTKACP1TYK2SCN9A | |
| SCHEMBL12045202 | 0.84 | BTK (0.40) | MPLBTKACP1TYK2 | |
| SCHEMBL12025120 | 0.84 | BTK (0.48) | MPLBTK | |
| SCHEMBL19981666 | 0.84 | BTK (0.48) | MPLBTK | |
| SCHEMBL12025121 | 0.84 | BTK (0.48) | MPLBTK | |
| SCHEMBL9985299 | 0.84 | BTK (0.48) | MPLBTK | |
| SCHEMBL19981730 | 0.75 | ACP1 (0.44) | MPLACP1SCN9A | |
| SCHEMBL12025215 | 0.70 | BTK (0.55) | BTK | |
| SCHEMBL1423849 | 0.69 | BTK (0.51) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |