Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.35 |
| ▸ | MPL | P40238 | 4/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12025103 | 0.75 | MPL (0.35) | ACP1MPLSCN9A | |
| SCHEMBL12025119 | 0.75 | MPL (0.35) | ACP1MPLSCN9A | |
| SCHEMBL19981727 | 0.75 | MPL (0.35) | ACP1MPLSCN9A | |
| SCHEMBL12045202 | 0.74 | BTK (0.40) | ACP1MPL | |
| SCHEMBL2466256 | 0.73 | ACP1 (0.42) | ACP1MKNK1MKNK2SCN9A | |
| SCHEMBL31075101 | 0.65 | TGFBR1 (0.47) | MKNK1MKNK2MPL | |
| SCHEMBL27998656 | 0.63 | MAPK10 (0.56) | ACP1MKNK1MKNK2MPL | |
| SCHEMBL30263685 | 0.62 | MPL (0.47) | MKNK1MKNK2MPLSCN9A | |
| SCHEMBL12045170 | 0.62 | GSK3A (0.41) | ACP1MKNK1MKNK2MPL | |
| SCHEMBL22084661 | 0.62 | HRH3 (0.36) | ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |