Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493858 | 0.89 | BTK (0.59) | BTKWDR5PDCD1CD274FGR | |
| SCHEMBL19981684 | 0.86 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL19981660 | 0.81 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL19981771 | 0.80 | BTK (0.50) | BTKFGRSRCTECBMX | |
| SCHEMBL2491712 | 0.80 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL19981864 | 0.80 | BTK (0.49) | BTKFGRSRCTECBMX | |
| SCHEMBL2493503 | 0.78 | BTK (0.61) | BTKFGRSRCTECBMX | |
| SCHEMBL19981754 | 0.78 | BTK (0.55) | BTKFGRSRCTECBMX | |
| SCHEMBL19981682 | 0.76 | BTK (0.51) | BTKFGRSRCTECBMX | |
| SCHEMBL2527943 | 0.75 | BTK (0.61) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |