Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348039 | 1.00 | CARM1 (0.48) | CARM1PRMT6PRMT8CA12CA1 | |
| SCHEMBL1307631 | 0.98 | CARM1 (0.50) | CARM1PRMT6PRMT8CA12CA1 | |
| SCHEMBL5748707 | 0.93 | — | — | |
| SCHEMBL14431493 | 0.88 | — | — | |
| SCHEMBL13527580 | 0.87 | HRH3 (0.56) | CARM1PRMT6PRMT8HRH3ALDH1A1 | |
| SCHEMBL1307277 | 0.87 | HRH3 (0.50) | CARM1PRMT6PRMT8HRH3MAPT | |
| SCHEMBL1781619 | 0.84 | HRH3 (0.52) | CARM1PRMT6PRMT8HRH3ALDH1A1 | |
| SCHEMBL1306927 | 0.84 | HRH3 (0.46) | CARM1PRMT6PRMT8HRH3GNAI3 | |
| SCHEMBL6538152 | 0.81 | CXCR4 (0.52) | CARM1PRMT6PRMT8HRH3GNAI3 | |
| SCHEMBL1785087 | 0.80 | GNAI3 (0.44) | CARM1PRMT6PRMT8GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053222-A1 | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | RESEARCH TRAINGLE INSTITUTE (US) | 2018-03-22 | — | — | WO | disclosed |