Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982160 | 1.00 | YAP1 (0.97) | YAP1KDM4ETSHRL3MBTL1 | |
| SCHEMBL19982187 | 0.99 | YAP1 (0.95) | YAP1KDM4EL3MBTL1 | |
| SCHEMBL19982186 | 0.98 | YAP1 (1.00) | YAP1KDM4ETSHR | |
| SCHEMBL19982185 | 0.97 | YAP1 (1.00) | YAP1TSHR | |
| SCHEMBL23296249 | 0.97 | YAP1 (1.00) | YAP1TSHR | |
| SCHEMBL19974531 | 0.91 | YAP1 (0.81) | YAP1KDM4EL3MBTL1 | |
| SCHEMBL23296259 | 0.90 | YAP1 (0.82) | YAP1 | |
| SCHEMBL19982189 | 0.90 | YAP1 (0.82) | YAP1 | |
| SCHEMBL22929117 | 0.90 | YAP1 (0.88) | YAP1 | |
| SCHEMBL19975444 | 0.90 | YAP1 (0.79) | YAP1KDM4ETSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |