Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.73 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25922255 | 0.91 | YAP1 (0.74) | YAP1PPARG | |
| Hydrochloric Acid SCHEMBL28874615 | 0.90 | YAP1 (0.68) | YAP1PPARG | |
| Hydrochloric Acid SCHEMBL28874618 | 0.90 | YAP1 (0.68) | YAP1PPARG | |
| SCHEMBL19982136 | 0.88 | YAP1 (0.75) | YAP1PPARG | |
| SCHEMBL19982180 | 0.88 | YAP1 (0.75) | YAP1PPARG | |
| Hydrochloric Acid SCHEMBL30117562 | 0.87 | YAP1 (0.74) | YAP1PPARG | |
| SCHEMBL19982081 | 0.87 | YAP1 (0.80) | YAP1PPARG | |
| SCHEMBL19982106 | 0.86 | YAP1 (0.72) | YAP1PPARG | |
| SCHEMBL19982058 | 0.86 | YAP1 (0.77) | YAP1 | |
| SCHEMBL19982135 | 0.86 | YAP1 (0.83) | YAP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |