Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 11/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 7/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.30 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210691 | 0.86 | SYK (0.47) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL19982833 | 0.83 | SYK (0.42) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL19983154 | 0.82 | SYK (0.42) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL16394370 | 0.80 | SYK (0.45) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19983166 | 0.80 | SYK (0.40) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL19982840 | 0.79 | SYK (0.40) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15221162 | 0.79 | SYK (0.44) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL15221185 | 0.78 | SYK (0.46) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL15210970 | 0.78 | SYK (0.41) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982766 | 0.76 | SYK (0.37) | SYKEIF2AK4JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |