Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 15/20 | 0.36 |
| ▸ | JAK3 | P52333 | 7/20 | 0.36 |
| ▸ | JAK1 | P23458 | 11/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16394844 | 0.86 | SYK (0.45) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982833 | 0.84 | SYK (0.42) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982840 | 0.83 | SYK (0.40) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982766 | 0.82 | SYK (0.37) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19983154 | 0.82 | SYK (0.42) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL16394366 | 0.81 | SYK (0.48) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982813 | 0.80 | SYK (0.43) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982784 | 0.79 | SYK (0.39) | SYKEIF2AK4JAK2JAK1 | |
| SCHEMBL15210519 | 0.77 | SYK (0.45) | SYKEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL19982960 | 0.76 | SYK (0.36) | SYKEIF2AK4JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |