Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23023495 | 1.00 | TDP1 (0.54) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL21152481 | 0.89 | FOLH1 (0.50) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL19983324 | 0.89 | FOLH1 (0.50) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL19983040 | 0.87 | TDP1 (0.53) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL21152641 | 0.86 | FOLH1 (0.46) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL19983187 | 0.85 | TDP1 (0.53) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL25660426 | 0.85 | CTSK (0.54) | TDP1ATMFOLH1PAX8 | |
| SCHEMBL19983059 | 0.85 | CTSK (0.54) | TDP1ATMFOLH1PAX8 | |
| SCHEMBL19983238 | 0.83 | TDP1 (0.52) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL24992894 | 0.83 | EPHX2 (0.52) | TDP1NPSR1FOLH1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |