SCHEMBL19983080

SCHEMBL19983080

CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCc3cn(-c4cccc(C(=O)N[C@@H](CCCCN)C(=O)COc5c(F)cccc5F)c4)nn3)n1S2(F)F

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSH P09668 1/20 0.37
CTSK P43235 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19983082 0.83 PARP14 (0.39)
SCHEMBL23023432 0.80 CTSH (0.49) CTSHCTSK
SCHEMBL25658857 0.79 ESRRA (0.38)
SCHEMBL21153288 0.78 ESRRA (0.37)
SCHEMBL21152628 0.78 ESRRA (0.38)
SCHEMBL21152666 0.78 ESRRA (0.38)
SCHEMBL21152627 0.73 CA12 (0.61)
SCHEMBL19983271 0.73 CA12 (0.61)
SCHEMBL21153279 0.73 CA12 (0.61)
SCHEMBL30716860 0.73 CA12 (0.61)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018053353-A1 KETONE INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2018-03-22 WO disclosed