Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16238217 | 0.60 | MAOA (0.54) | MAOAMAOBALKMIFNOTUM | |
| SCHEMBL29300000 | 0.56 | NOTUM (0.66) | MAOACA1CA2MIFNOTUM | |
| SCHEMBL16785620 | 0.56 | CA2 (0.62) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL16250023 | 0.55 | CA1 (0.64) | MAOAMAOBALKCA12CA1 | |
| SCHEMBL27423391 | 0.54 | KDM1A (0.54) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL19365353 | 0.54 | CA1 (0.60) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL4583569 | 0.54 | TP53 (0.70) | NOTUM | |
| SCHEMBL29299489 | 0.53 | MIF (0.58) | MAOAMIFNOTUM | |
| SCHEMBL27430548 | 0.53 | CA1 (0.58) | CA12CA1CA2CA9RXRA | |
| SCHEMBL22416987 | 0.53 | MAOA (0.46) | PARP14MAOAMAOBCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |