Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.38 |
| ▸ | CDK2 | P24941 | 7/20 | 0.38 |
| ▸ | TTK | P33981 | 6/20 | 0.37 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212574 | 0.83 | SYK (0.58) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL19982814 | 0.83 | SYK (0.50) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL15210942 | 0.82 | JAK2 (0.53) | SYKEIF2AK4KDRCCNA2CDK2 | |
| SCHEMBL16394411 | 0.81 | SYK (0.55) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL15210956 | 0.81 | SYK (0.51) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL15210403 | 0.81 | SYK (0.53) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL15207760 | 0.79 | SYK (0.56) | SYKEIF2AK4KDRCCNA2CDK2 | |
| SCHEMBL19983170 | 0.79 | SYK (0.49) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL15210725 | 0.79 | SYK (0.56) | SYKEIF2AK4CCNA2CDK2TTK | |
| SCHEMBL15210746 | 0.79 | CCNA2 (0.62) | SYKEIF2AK4CCNA2CDK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |