Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.38 |
| ▸ | CDK1 | P06493 | 6/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.38 |
| ▸ | CDK9 | P50750 | 5/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210956 | 0.86 | SYK (0.51) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL15210403 | 0.83 | SYK (0.53) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL19982814 | 0.81 | SYK (0.50) | SYKEIF2AK4METCDK2CCNB2 | |
| SCHEMBL19983168 | 0.79 | SYK (0.54) | SYKEIF2AK4CDK2CDK9TTK | |
| SCHEMBL15212553 | 0.79 | CDK2 (0.63) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL15210580 | 0.76 | CDK1 (0.65) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL15221150 | 0.76 | CCNB2 (0.61) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL15212574 | 0.75 | SYK (0.58) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL15210540 | 0.74 | SYK (0.56) | SYKEIF2AK4CDK2CCNB2CDK1 | |
| SCHEMBL16394411 | 0.74 | SYK (0.55) | SYKEIF2AK4CDK2CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |