Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152672 | 1.00 | CTSK (0.49) | CTSKCTSLTDP1ATMMAPT | |
| SCHEMBL22460388 | 0.97 | CTSK (0.47) | CTSKCTSLTDP1ATMMAPT | |
| SCHEMBL22460387 | 0.97 | CTSK (0.47) | CTSKCTSLTDP1ATMMAPT | |
| SCHEMBL22460570 | 0.87 | CTSK (0.42) | CTSKCTSLTDP1ATMMAPT | |
| SCHEMBL19972814 | 0.85 | CTSK (0.66) | CTSKCTSL | |
| SCHEMBL19972817 | 0.85 | CTSK (0.66) | CTSKCTSL | |
| SCHEMBL22445762 | 0.85 | CTSK (0.49) | CTSKCTSL | |
| SCHEMBL22445759 | 0.85 | CTSK (0.49) | CTSKCTSL | |
| SCHEMBL19983251 | 0.84 | CTSK (0.47) | CTSKCTSLTDP1ATMMEN1 | |
| SCHEMBL19983282 | 0.82 | CTSK (0.62) | CTSKTDP1ATMPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |