Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152680 | 0.92 | TDP1 (0.53) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL19983279 | 0.91 | CA1 (0.56) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL19983227 | 0.84 | TDP1 (0.50) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL19983308 | 0.81 | CA1 (0.56) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL19983005 | 0.79 | TDP1 (0.48) | TDP1NPSR1MAPTKDM4EATM | |
| SCHEMBL19983071 | 0.79 | TDP1 (0.48) | TDP1NPSR1MAPTKDM4EATM | |
| SCHEMBL18236311 | 0.79 | TDP1 (0.46) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL19983306 | 0.79 | TDP1 (0.46) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL14090964 | 0.79 | NPSR1 (0.50) | TDP1NPSR1MAPTKDM4ECA1 | |
| SCHEMBL19983238 | 0.78 | TDP1 (0.52) | TDP1NPSR1MAPTKDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |