Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18236311 | 0.91 | TDP1 (0.46) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL19983222 | 0.90 | CA1 (0.42) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL17646344 | 0.87 | CA1 (0.40) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL19983057 | 0.85 | CTSH (0.41) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL19983227 | 0.83 | TDP1 (0.50) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL28172916 | 0.83 | ALB (0.52) | TDP1NPSR1MAPTCA1CA2 | |
| SCHEMBL17646270 | 0.83 | ALB (0.52) | TDP1NPSR1MAPTCA1CA2 | |
| SCHEMBL19688865 | 0.82 | ALB (0.42) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL19983028 | 0.81 | ALB (0.43) | TDP1ATMNPSR1MAPTKDM4E | |
| SCHEMBL19983279 | 0.81 | CA1 (0.56) | TDP1ATMNPSR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |