Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 4/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | CCR1 | P32246 | 9/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13085684 | 0.91 | MLNR (0.52) | MLNRGPR119CCR1KCNH2 | |
| SCHEMBL2003276 | 0.89 | MLNR (0.49) | MLNRGPR119CCR1KCNH2MEN1 | |
| SCHEMBL1995197 | 0.89 | MLNR (0.63) | MLNRGPR119CCR1KCNH2MEN1 | |
| SCHEMBL2856258 | 0.89 | MLNR (0.53) | MLNRCCR1KCNH2MEN1NPC1 | |
| SCHEMBL2002043 | 0.88 | MLNR (0.46) | MLNRGPR119CCR1KCNH2MEN1 | |
| SCHEMBL1997045 | 0.87 | MLNR (0.48) | MLNRGPR119CCR1KCNH2MEN1 | |
| SCHEMBL1996928 | 0.86 | GPR119 (0.49) | MLNRGPR119CCR1 | |
| SCHEMBL1999297 | 0.83 | MLNR (0.42) | MLNRGPR119CCR1KCNH2 | |
| SCHEMBL1995580 | 0.83 | MLNR (0.64) | MLNRGPR119 | |
| SCHEMBL1999376 | 0.82 | MLNR (0.54) | MLNRGPR119MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |
| WO-2009068552-A1 | PIPERAZINYL-SULFONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |