Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799032 | 0.77 | CYP1A2 (0.43) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL799196 | 0.77 | CYP1A2 (0.43) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL10941145 | 0.77 | CYP1A2 (0.43) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL357615 | 0.77 | CYP1A2 (0.43) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL220386 | 0.77 | — | — | |
| SCHEMBL14145678 | 0.77 | — | — | |
| SCHEMBL7972094 | 0.75 | TSHR (0.38) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL7972089 | 0.75 | TSHR (0.38) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL13382875 | 0.75 | TSHR (0.38) | TSHRMAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL13383332 | 0.75 | TSHR (0.38) | TSHRMAPTPOLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053126-A1 | INHIBITION OF BMP SIGNALING, COMPOUNDS, COMPOSITIONS AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2018-03-22 | — | — | WO | disclosed |