Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815374 | 0.89 | POLB (0.73) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL6815339 | 0.85 | POLB (0.77) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL3562732 | 0.85 | NPC1 (0.69) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL29956346 | 0.83 | NPC1 (0.62) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL6818908 | 0.82 | NPC1 (0.64) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL6814497 | 0.81 | POLB (0.75) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL6810773 | 0.80 | POLB (0.73) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL15330790 | 0.80 | MAOB (0.64) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL29956938 | 0.80 | MAOB (0.64) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB | |
| SCHEMBL1756442 | 0.77 | POLB (0.73) | NPC1RAB9AHSP90AA1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345904-A1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | Chiesi Farmaceutici S.p.a. (IT) | 2018-07-11 | — | — | EP | disclosed |
| EP-2928889-B1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2018-03-21 | — | — | EP | disclosed |