Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22416799 | 1.00 | ESR1 (0.43) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL7176631 | 0.87 | ESR1 (0.50) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL9227464 | 0.86 | ESR1 (0.39) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL11800593 | 0.81 | ESR1 (0.45) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL17755167 | 0.79 | ESR1 (0.43) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL10699377 | 0.79 | TRPA1 (0.44) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL19847785 | 0.78 | ESR1 (0.42) | ESR1TSHRACHEADRA2AADRA2B | |
| SCHEMBL20228717 | 0.78 | CYP3A4 (0.38) | TSHRACHESLC6A2SLC6A4CYP3A4 | |
| SCHEMBL3918911 | 0.78 | ESR1 (0.42) | ESR1TSHRACHECYP19A1ACP3 | |
| SCHEMBL3918915 | 0.78 | ESR1 (0.42) | ESR1TSHRACHECYP19A1ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3279188-B1 | AXIALLY CHIRAL ISOMERS, AND PREPARATION METHODS THEREFOR AND PHARMACEUTICAL USES THEREOF | MEDSHINE DISCOVERY INC (CN) | 2020-09-09 | — | — | EP | disclosed |
| US-10183915-B2 | Axially chiral isomers, and preparation methods therefor and pharmaceutical uses thereof | MEDSHINE DISCOVERY INC. (CN) | 2019-01-22 | — | — | US | disclosed |
| US-20180079731-A1 | AXIALLY CHIRAL ISOMERS, AND PREPARATION METHODS THEREFOR AND PHARMACEUTICAL USES THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079731-A1 | AXIALLY CHIRAL ISOMERS, AND PREPARATION METHODS THEREFOR AND PHARMACEUTICAL USES THEREOF | CYP4F11, CYP4A11, SLC39A11 | ESR1 3125/4885TSHR 3847/4885ACHE 2128/4885 |
| US-10183915-B2 | Axially chiral isomers, and preparation methods therefor and pharmaceutical uses thereof | CYP4F11, CYP4A11, SLC39A11 | ESR1 3125/4885TSHR 3847/4885ACHE 2128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.