SCHEMBL1998616

SCHEMBL1998616

CCOC(=O)c1ccc(C(F)(F)F)cc1C(F)(F)F

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.60
KDM4E B2RXH2 3/20 0.49
NPSR1 Q6W5P4 1/20 0.49
MRGPRX4 Q96LA9 1/20 0.48
CFTR P13569 1/20 0.48
CA12 O43570 2/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA7 P43166 2/20 0.47
CA9 Q16790 2/20 0.47
CA14 Q9ULX7 2/20 0.47
TSHR P16473 1/20 0.47
MAPT P10636 3/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1998119 0.88 CES2 (0.65) CES2KDM4ENPSR1MRGPRX4CFTR
SCHEMBL4691963 0.87 CA12 (0.50) CES2KDM4ENPSR1MRGPRX4CFTR
SCHEMBL16647662 0.84 MRGPRX4 (0.51) KDM4ENPSR1MRGPRX4CFTRCA12
SCHEMBL5943406 0.84 CA12 (0.64) KDM4EMRGPRX4CFTRCA12CA1
SCHEMBL28195998 0.84 MRGPRX4 (0.48) CES2KDM4ENPSR1MRGPRX4CFTR
SCHEMBL30172263 0.84 TSHR (0.52) KDM4ENPSR1CA12CA1CA2
SCHEMBL540542 0.84 TSHR (0.52) KDM4ENPSR1CA12CA1CA2
SCHEMBL11336074 0.83 CFTR (0.70) KDM4ENPSR1MRGPRX4CFTRCA12
SCHEMBL8997654 0.83 MRGPRX4 (0.47) CES2KDM4ENPSR1MRGPRX4CFTR
SCHEMBL7001729 0.83 MRGPRX4 (0.47) CES2KDM4ENPSR1MRGPRX4CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US disclosed
EP-2338935-B1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS CO LTD (JP) 2012-12-12 EP disclosed
US-20110172336-A1 FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS ASAHI GLASS COMPANY, LIMITED (JP) 2011-07-14 US disclosed
EP-2338935-A1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS COMPANY, LIMITED (JP) 2011-06-29 EP disclosed