SCHEMBL19986347

SCHEMBL19986347

CC/C=C\Cc1ccc(-c2ccc(C3CCCCC3)cc2)c(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 1/20 0.40
APP P05067 1/20 0.40
FFAR4 Q5NUL3 1/20 0.36
CHKA P35790 1/20 0.34
SIGMAR1 Q99720 1/20 0.33
PRKAB2 O43741 1/20 0.33
PRKAG1 P54619 1/20 0.33
PRKAA2 P54646 1/20 0.33
PRKAA1 Q13131 1/20 0.33
PRKAG3 Q9UGI9 1/20 0.33
PRKAG2 Q9UGJ0 1/20 0.33
PRKAB1 Q9Y478 1/20 0.33
S1PR1 P21453 4/20 0.32
NOS3 P29474 2/20 0.32
NOS1 P29475 2/20 0.32
NOS2 P35228 2/20 0.32
HSP90AA1 P07900 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19985423 0.89 ESR2 (0.33) CYP3A4CYP2C9APPFFAR4CHKA
SCHEMBL19985428 0.86 CYP2C9 (0.41) CYP3A4CYP2C9FFAR4MAPTKMT2A
SCHEMBL24778683 0.84 CYP3A4 (0.47) CYP3A4CYP2C9APPFFAR4CHKA
SCHEMBL19985434 0.84 CYP2C9 (0.34) CYP2C9FFAR4GAAMAPTKMT2A
SCHEMBL19985453 0.82 MAPT (0.34) CYP2C9GAAMAPTKMT2ADGAT1
SCHEMBL19985447 0.82 MAPT (0.34) CYP2C9GAAMAPTKMT2ADGAT1
SCHEMBL19986387 0.82 FEN1 (0.33) SIGMAR1
SCHEMBL7568415 0.82 CYP3A4 (0.43) CYP3A4CYP2C9APPFFAR4CHKA
SCHEMBL15255860 0.81 CYP3A4 (0.42) CYP3A4CYP2C9APPFFAR4CHKA
SCHEMBL12999617 0.79 FASN (0.34) CYP3A4CYP2C9APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180079959-A1 LIQUID CRYSTAL ELEMENT WITH NEGATIVE DIELECTRIC ANISOTROPY DIC CORPORATION (JP) 2018-03-22 US disclosed