SCHEMBL19986733

SCHEMBL19986733

Clc1cncc(Cl)c1N1CCCC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.67
CYP3A4 P08684 1/20 0.53
LMNA P02545 3/20 0.46
ALDH1A1 P00352 5/20 0.43
NPSR1 Q6W5P4 2/20 0.43
MAPT P10636 1/20 0.43
KDM4E B2RXH2 1/20 0.42
HCAR2 Q8TDS4 1/20 0.40
CHRNB2 P17787 2/20 0.39
CHRNA4 P43681 2/20 0.39
CHKA P35790 1/20 0.38
CCNC P24863 1/20 0.38
CDK8 P49336 1/20 0.38
ATR Q13535 1/20 0.37
CHRNA1 P02708 1/20 0.37
CHRNA7 P36544 1/20 0.37
CYP1A2 P05177 1/20 0.36
POLB P06746 3/20 0.36
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15779347 0.86 ADRB2 (0.52) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL21599143 0.82 ADRB2 (0.53) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL28789056 0.82 ADRB2 (0.62) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL2063946 0.82 ADRB2 (0.62) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL1938752 0.80 ADRB2 (0.60) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL19986489 0.80 ADRB2 (0.50) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL21599186 0.80 ADRB2 (0.50) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL30485938 0.78 HCAR2 (0.49) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL16707783 0.78 ADRB2 (0.49) ADRB2CYP3A4LMNAALDH1A1NPSR1
SCHEMBL13419067 0.77 CYP3A4 (0.63) ADRB2CYP3A4CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018050110-A1 NOVEL CAPSID PROTEIN ASSEMBLY INHIBITOR 正大天晴药业集团股份有限公司 2018-03-22 WO disclosed