Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12450345 | 0.90 | PSEN1 (0.40) | HSD17B10CHRM2CHRM1CHRM3MEN1 | |
| SCHEMBL25949561 | 0.87 | CHRM2 (0.44) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL27059386 | 0.87 | CHRM2 (0.44) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL178721 | 0.81 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1ALDH1A1LMNA | |
| SCHEMBL357043 | 0.81 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1ALDH1A1LMNA | |
| SCHEMBL357042 | 0.81 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1ALDH1A1LMNA | |
| SCHEMBL25124432 | 0.79 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2NPC1ALDH1A1CHRM2 | |
| SCHEMBL25945745 | 0.78 | MAP4K4 (0.38) | HSD17B10SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL25945800 | 0.78 | KDM2B (0.38) | ALDH1A1CHRM2CHRM1CHRM3MEN1 | |
| SCHEMBL17631439 | 0.77 | USP2 (0.40) | HSD17B10SMN1; SMN2CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154973-B1 | TRICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-21 | — | — | EP | disclosed |