Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.71 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.71 |
| ▸ | FYN | P06241 | 4/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.70 |
| ▸ | CDK2 | P24941 | 4/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.70 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.70 |
| ▸ | PIM1 | P11309 | 10/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.67 |
| ▸ | CDK9 | P50750 | 3/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.63 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29781258 | 0.89 | FYN (0.70) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL102751 | 0.83 | DYRK1A (0.76) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL2945964 | 0.83 | FYN (1.00) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL24736875 | 0.83 | PIM1 (0.61) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL14898077 | 0.82 | FYN (0.61) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL24736843 | 0.82 | PIM1 (0.83) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL19987067 | 0.82 | PIM1 (0.83) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL24737157 | 0.82 | FYN (0.94) | DYRK1ADYRK2FYNCCNA2CDK2 | |
| SCHEMBL137404 | 0.82 | PIM1 (0.84) | FYNPIM1KCNH2PIM3PIM2 | |
| SCHEMBL19987123 | 0.82 | DYRK3 (0.69) | DYRK1ADYRK2FYNCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |