Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.83 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.81 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.81 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL136162 | 0.91 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2JAK2 | |
| SCHEMBL102865 | 0.91 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2JAK2 | |
| SCHEMBL14639168 | 0.90 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2JAK2 | |
| SCHEMBL14639167 | 0.90 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2JAK2 | |
| SCHEMBL24736843 | 0.90 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL19987067 | 0.90 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL21475438 | 0.89 | PIM1 (0.79) | PIM1KCNH2PIM3PIM2JAK2 | |
| Nuvisertib SCHEMBL30863763 | 0.89 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2JAK2 | |
| Nuvisertib SCHEMBL102560 | 0.89 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2JAK2 | |
| Nuvisertib SCHEMBL19986953 | 0.89 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |