SCHEMBL19987115

SCHEMBL19987115

CC1(O)CCC(Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 20/20 1.00
KCNH2 Q12809 3/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL138794 1.00 PIM1 (1.00) PIM1KCNH2
SCHEMBL102159 1.00 PIM1 (1.00) PIM1KCNH2
SCHEMBL20794682 1.00 PIM1 (1.00) PIM1KCNH2
SCHEMBL23299241 0.89 PIM1 (0.80) PIM1KCNH2
SCHEMBL16216057 0.89 PIM1 (0.80) PIM1KCNH2
SCHEMBL19986988 0.87 PIM1 (0.84) PIM1KCNH2
SCHEMBL19986920 0.87 PIM1 (0.82) PIM1KCNH2
SCHEMBL19986912 0.86 PIM1 (0.82) PIM1KCNH2
SCHEMBL14639326 0.86 PIM1 (0.77) PIM1KCNH2
SCHEMBL103173 0.85 PIM1 (1.00) PIM1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2734205-B1 HETEROCYCLIC PROTEIN KINASE INHIBITORS TOLERO PHARMACEUTICALS INC (US) 2018-03-21 EP disclosed