Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbitol SCHEMBL11021828 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL1063291 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL6690019 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL10952803 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL9470802 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27402277 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL1241895 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29085543 | 0.89 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Demannose SCHEMBL27965009 | 0.85 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL20481325 | 0.83 | LMNA (0.53) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298148-A2 | METHOD AND HYBRIDS FOR TARGETED NUCLEIC ACID EDITING IN PLANTS | KWS SAAT SE (DE) | 2018-03-28 | — | — | EP | disclosed |